Where is trh released from

The effect of thyrotropin-releasing hormone on the pituitary gland is to trigger thyroid stimulating hormone release, which, in turn stimulates the thyroid gland to make more thyroid hormone.

Thyrotropin-releasing hormone in its pharmaceutical formulation of 'protirelin' was widely used as a drug to test whether someone had thyroid overactivity. However, there are now more sensitive measurements that can detect very low levels of thyroid stimulating hormone in the blood. Thyrotropin-releasing hormone tests are still occasionally carried out but are normally used for the diagnosis of conditions caused by resistance to thyroid hormone action. If a person has too little thyrotropin-releasing hormone, they will develop thyroid underactivity hypothyroidism.

This is a rare condition, usually due to an injury or tumour which destroys this area of the hypothalamus. This situation is referred to as secondary or central hypothyroidism. About Contact Events News. Search Search. You and Your Hormones. Students Teachers Patients Browse.

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Thyroid Hormone Production and Function. Topic Overview The thyroid gland uses iodine from food to make two thyroid hormones: triiodothyronine T3 and thyroxine T4.

When the hypothalamus and pituitary are working normally, they sense when: Thyroid hormone levels are low, so they secrete more TRH and TSH, which stimulates the thyroid to make more hormones. Thyroid hormone levels are too high, so they secrete less TRH and TSH, which reduces hormone production by the thyroid.

Disease or tumors of the pituitary gland can affect this process. Thyroid hormones affect every cell and all the organs of the body.