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Too much of this "female" hormone could lead to a host of well-known problems among bodybuilders -- gynecomastia, low sex drive. I do think my psychiatrist might be willing to get that for me. Arimidex, also known by its chemical name anastrozole, is an aromatase inhibitor -- a breast cancer drug. While steroids and growth hormone make headlines when athletes abuse them, breast cancer drugs are a lesser-known staple of doping regimens, for athletes and "weekend warriors" alike. Star therapies of the breast oncology world -- like tamoxifen Nolvadex and exemestane Aromasin -- provide an easy, non-injectable means of cutting estrogen's unwanted side effects.

And bodybuilders are packing other little-known pharmaceuticals into their routines -- some of which, like ghrelin mimetics and selective androgen receptor modulators SARMs , are still under investigation in clinical trials and are not available on any regulated market. Weightlifters don't seem to have a preference for either class of anti-estrogens. There are the selective estrogen receptor modulators SERMs like tamoxifen, or the aromatase inhibitors like anastrozole.

Both classes mitigate the effects of estrogen, which is metabolized from testosterone. When testosterone levels are high, estrogen levels also tend to increase as a natural byproduct. Rowlett's organization champions drug-free bodybuilding, and prescription anti-estrogens are on the group's list of banned substances , modeled on that of the International Olympic Committee.

These breast cancer drugs are also on the prohibited performance-enhancing drugs lists from the U. Abuse of breast cancer drugs isn't limited to top athletes. There are no data on how widely used anti-estrogens are in this community, but Rowlett says it's common practice.

Given that they're prescription drugs, the obvious question is how bodybuilders are getting their hands on them. Rowlett says family practice physicians tend to write the scripts directly to those who are working out. There is also the potential for doctor shopping if one clinician refuses, as Thomas pointed out in his video.

And, of course, there's an underground market that anyone with Internet access can peruse. On its homepage, HardcorePeptides.

Some may simply be scams to obtain credit card information, a common problem that many of the sites denounce and attempt to reassure potential buyers with customer service hot lines and other security measures. A spokesperson for AstraZeneca, which makes Nolvadex and Arimidex, told MedPage Today that diversion and counterfeiting of its products for this purpose "isn't something we're aware of.

Then there are the specialized supplements -- which don't require a prescription -- that claim to target estrogen and aromatase, readily up for sale on Amazon.

But like the rest of the unregulated supplement industry, there's no guarantee that these bottles contain what's on their labels. Researchers have been interested in ghrelin, called the hunger hormone for its ability to spark appetite, as a potential target for obesity treatment, but it's had more practical application in wasting disease.